After the sacrifices of Dr. Miles Dyson and T-800 Model 101 Terminator, the Connors find themselves once again being stalked by Skynet's agents from the future. Realizing their nightmare isn't over, they decide to stop running and focus on preventing the birth of Skynet. With the aid of Cameron Phillips, a beautiful girl who has a mysterious past also linked to the future, Derek Reese, a Tech-Com soldier from the future whose past is linked with the Connors, and FBI Agent James Ellison, who were assigned to capture the Connors but joins them after his own encounter with one of the machines, they begin a quest stop the United States military and Cyberdyne Corporation from creating the program that will bring humanity to an end.