Based on a program of study developed at the Children's Hospital Boston, Department of Anesthesiology, Perioperative and Pain Medicine, Pediatric Anesthesiology Review: Clinical Cases for Self-Assessment provides essential medical information for the subspecialty of pediatric anesthesiology. Illustrating the broad spectrum of the pediatric anesthesiologist’s practice, this book utilizes an interactive question and answer dialogue which imitates the simplicity of conversation and affords the reader high-yield benefits. The case-based approach encourages readers to collaborate with colleagues, improve their oral presentation skills, and prepare for challenging situations by explaining various anesthesia care plans and why specific data are required before and during the care of the pediatric patient.

"The book provides a comprehensive overview of many aspects of the lead generation process . . . The book delivers a good introduction to the process of lead generation for novice researchers. It is also useful for more experienced scientists to update their knowledge and/or to identify some new details." (ChemMedChem, October 2010)

Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.

The theory of a stem-cell origin of cancer is neither ground breaking nor earth shattering. Many prominent investigators have established the foundation for this concept and performed the vital experiments to support its validity and merit. The purpose of this book is to illustrate how this theory may completely transform our current views and perspective about cancer. It is anticipated that the variety of ramifications of a stem-cell origin of cancers will be embraced by the medical research community to bring new treatment modalities to the cancer patient.

Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.

Among malignant tumors, adenocarcinomas of the esophagogastric junction show the highest increase in incidence over the past three decades in Western industrialized countries. This special volume, with contributions from experts in the field, covers all aspects of the disease. Etiology, pathogenesis, classification, and clinical staging are discussed, and there is special emphasis on state of the art treatment techniques. The latter range from endoscopic mucosal resections or limited surgical resections for early cancers to multimodality treatment options for locally advanced tumors. Emerging quality issues in surgical management are addressed. Detailed attention is also paid to other important recent developments, including molecular response prediction, early metabolic response evaluation by PET and PET-CT, the diagnosis of micrometastases, and the use of sentinel node technology. This volume will be of interest to all clinicians concerned with the diagnosis and management of this malignancy.

Of all the techniques used to treat non melanoma skin cancer, the highest cure rates belong to the Mohs surgical procedure. Critical to this technique is optimal preparation and interpretation of frozen sections. With more than 400 high resolution figures, the Atlas of Mohs and Frozen Section Cutaneous Pathology is the premier textbook on the topic, serving as a highly practical guide to microscopic analysis, diagnosis, and discrimination of common and problematic cutaneous neoplasms.

Substance abuse is, and has always been, an indisputable fact of life. People – especially young people – abuse various legal and illegal substances for any number of reasons: to intensify feelings, to achieve deeper consciousness, to escape reality, to self-medicate. And as substance-abusing teenagers mature, they pose particular challenges to the professionals charged with keeping them clean and sober and helping them maintain recovery into adulthood.

The scalp and hair are subject to both intrinsic or physiologic aging and extrinsic or premature aging caused by external factors. This comprehensive and reader-friendly book offers an up-to-date overview on all aspects of hair aging, including in particular the two main streams of interest: the aesthetic problem, which relates to everything that happens outside the skin, and the biologic problem, which concerns the "secret life" of the hair follicle in the depth of the skin. Internationally recognized experts provide detailed contributions on the biologic basis of hair aging and current concepts for its diagnosis, treatment, and prevention. The intrinsic and extrinsic modulating factors for hair growth and pigmentation are explained and future directions for therapeutic intervention are examined.

"Noninvasive Peripheral Arterial Diagnosis" is the newest definitive text on the current techniques used in assessing vascular disorders. Readers will receive authoritative information and will be guided through the establishment and accreditation of a vascular laboratory and introduced to the physics of diagnostic testing.

Ideal for family physicians, internists, pediatricians, emergency physicians and all involved in clinical diagnosis, this new edition provides need-to-know information when ordering the most clinically appropriate and cost-effective diagnostic imaging studies. Focused chapters target key questions for quick and easy reference for 300 clinical problems encountered in day-to-day practice.

This is the second edition of a comprehensive clinical handbook for nurses in pediatric hematology/oncology that presents in-depth information on pathophysiology, diagnosis, treatment, advanced assessment, and interventions. All chapters have been updated since the first edition, and additional chapters have been included where necessary. The book is divided into five sections: pediatric cancers, hematologic disorders, treatment of childhood cancer, side-effects of treatment and disease, and supportive and palliative care.

The new Fourth Edition of Bacterial Infections of Humans reflects a decade of important discoveries, technological progress, and valuable new therapies as well as emerging and reemerging infections, resistant strains of bacteria, and threats of bioterrorism. It offers accessible, up-to-date information across the range of disease entities.

Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics.

In the last decade, we have witnessed a striking maturation of our understanding of how neurons in the spinal cord control muscular activity and movement. Paradoxically, a host of new findings have revealed an unexpected versatility in the behavior of these well-studied neural elements and circuits. In this volume, the world's leading experts review the current state of our knowledge of motor control, outline their latest results and developments, and delineate the seminal unresolved questions in this vibrant field of research. The volume begins with a commentary and overview of our current understanding of the peripheral and spinal basis of motor control. The remainder of the volume is divided into seven sections, each focused on a different problem. The first chapter in each section provides some historical review and presages the experimental findings and hypotheses that are discussed in subsequent chapters.