To facilitate the development of novel drug delivery systems and biotechnology-oriented drugs, the need for new, yet to be developed, and approved excipients continues to increase. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems serves as a comprehensive source to improve understanding of excipients and forge potential new avenues for regulatory approval. This book presents detailed, up-to-date information on various aspects of excipient development, testing, and technological considerations for their use. It addresses specific details such as historical perspective, preclinical testing, safety, and toxicology evaluation, as well as regulatory, quality, and utility aspects. The text also describes best practices for use of various functional excipients and extensive literature references for all topics.

This book is written for researchers, instructors, advanced undergraduate students and beginning graduate students in the life sciences who wish to become more familiar with these and many other intriguing aspects of phenolic compounds. Topics covered include nomenclature, chemical properties, biosynthesis, including an up-to-date overview of the genetics controlling phenolic metabolism, isolation and characterization of phenolic compounds, phenolics used in plant defense, and the impact of phenolics on human health. The book is written in an accessible style, and assumes only basic knowledge of organic chemistry, biochemistry and cell physiology. More than 300 chemical structures and reaction schemes illustrate the text.

Marijuana is one of the most widely used drugs in the world. This book provides an extensive reference on the biology of marijuana and the role of molecular techniques in elucidating neuropharmacological aspects of cannabinoid receptors and the endogenous compounds that act upon them. Contributions from experts from around the world describe the interaction of cannabinoids and endocannabinoids on a wide range of biological functions including movement, memory and learning, pain, emotions, endocrine functions and many more. The Biology of Marijuana: From Gene to Behavior will be of interest to all scientists and clinicians interested in the biological effects and pharmacology of this drug.

This handbook seeks to facilitate the selection, design and operation of large-scale industrial crystallizers that process crystals with the proper size distribution, shape and purity sought - including cooling, evaporation, drowning-out reaction, melt, and related crystallization techniques. This new edition offers new results on direct-contact cooling crystallization. It lists the properties of over 170 organic and inorganic crystallization systems. An up-to-date review of the engineering science of crystallization, featuring well-organized and clear guidelines for the building, running and optimization of crystallizer operations. Offers new results on direct-contact cooling crystallization, measures of solubility and supersaturation, surface nucleation on crystals, and other advanced topics.

The Dictionary is the first updated source of Ayurvedic, Unani and Siddha synonyms of their botanical counterparts, after a gap of more than 30 years. The synonyms which appeared in "The Wealth of India" series (1948-1976) and in Chopra’s "Glossary of Indian Medicinal Plants" (1956) have been updated till January, 2007. More than 2000 medicinal plants of "The Ayurvedic Formulary of India" and "The Ayurvedic Pharmacopoeia of India" and more than 100 species of non-Indian origin, incorporated in "National Formulary of Unani Medicine" have been covered in the Dictionary. Divergent sources of Ayurvedic, Unani and Siddha herbs have been identified and a number of controversies have been sorted out. Pharmacognosy experts have selected important herbs, which were specially collected from leading pharamaceutical companies and pharmacopoeial laboratories and included in the dictionary as four colour photographs under the "Crude Herb Identification Guide" section. This is a unique feature and makes it an exclusive treat. The Dictionary has been presented in a user-friendly format, as a compact, handy, easy to use and moderately priced one-volume reference work. It unfolds hidden virtues and potentials of Indian herbs for busy professionals, researchers, practitioners of herbal as well as modern medicine, and library frequenters. It will prove a ready information source for students of botany, economic botany, pharmacy, agricultural and medical sciences, who aspire to have an edge over others and are keen to keep themselves abreast of the times.

Provides a broad understanding of the use of carbohydrates in organic synthesis, at postgraduate student level. Emphasizes retrosynthetic analysis, with discussion of why a particular synthetic route has been chosen, and mechanistic explanations are provided for key and novel reactions.

The bible of gas chromatography-offering everything the professional and the novice need to know about running, maintaining, and interpreting the results from GC Analytical chemists, technicians, and scientists in allied disciplines have come to regard Modern Practice of Gas Chomatography as the standard reference in gas chromatography. In addition to serving as an invaluable reference for the experienced practitioner, this bestselling work provides the beginner with a solid understanding of gas chromatographic theory and basic techniques. This new Fourth Edition incorporates the most recent developments in the field, including entirely new chapters on gas chromatography/mass spectrometry (GC/MS); optimization of separations and computer assistance; high speed or fast gas chromatography; mobile phase requirements: gas system requirements and sample preparation techniques; qualitative and quantitative analysis by GC; updated information on detectors; validation and QA/QC of chromatographic methods; and useful hints for good gas chromatography. As in previous editions, contributing authors have been chosen for their expertise and active participation in their respective areas. Modern Practice of Gas Chromatography, Fourth Edition presents a well-rounded and comprehensive overview of the current state of this important technology, providing a practical reference that will greatly appeal to both experienced chomatographers and novices.

New Perspectives on Aloe will cover research studies of aloe by the CAP (Creation Aloe Pharmaceuticals) team, which studied various aspects of aloe over a period of more than 10 years. The team was organized into two groups: the isolation and analysis group, which purified many components in terms of low molecular weight compounds, carbohydrates, proteins present in aloe, and the assay group, which determined the efficacy of those components. This type of target-oriented, organized research provides a model of how to conduct multidisciplinary research. The contents include a brief introduction of aloe, isolation, purification, and structural analysis of components, and various physiological effects of those components for possible use as health foods or drugs. Various functions identified were wound healing, angiogenesis, anti-allergy, skin whitening, stimulation of cell proliferation such as liver or kidney, protection against nephrotoxicity, and immune modulation. Moreover, we suggest standardization and quality control procedures for manufacturing raw aloe, and how to develop related products for successful application of aloe. This is important in Korea because last year the Korean government listed aloe as a health food for which the government establishes regulatory laws. Therefore, many scientists in Korea who are interested in studying health foods would be interested in this kind of text. Other major fields related to this kind of research will be medicine, biology, pharmaceutics, natural products and analytics.

This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties. With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.