"Integrating Large-Scale Genomic Information into Clinical Practice" ed. by S.Olson, S. Beachy, C. Giammaria, A. Berger

This report focuses on several key topics, including the analysis, interpretation, and delivery of genomic information plus workforce, ethical, and legal issues.

With these issues in mind and considering the potential impact that genomics information can have on the prevention, diagnosis, and treatment of disease, the Roundtable on Translating Genomic-Based Research for Health hosted a workshop on July 19, 2011, to highlight and identify the challenges and opportunities in integrating large-scale genomic information into clinical practice.

Contents
ABBREVIATIONS AND ACRONYMS
1 INTRODUCTION
2 THE REALIZATION OF GENOMIC MEDICINE
Shifting Research Paradigms
Clinical Applications of Genomic-Based Medicine
Addressing Obstacles and Defining a Path Forward
The ClinSeq Project
An Evolution of Medicine
3 THE ANALYSIS OF GENOMIC DATA
Challenges for Laboratories
Laboratory-Based Solutions
Meaningful Use of Test Results
Genomic Medicine in Practice
4 THE INTERPRETATION OF GENOMIC DATA
Data Interpretation from a Clinician’s Perspective
Integrating Genomics Data with Pathology
Using a Bioinformatics Model for Interpretation
Envisioning Clinical Genomics in 2020
5 THE DELIVERY OF GENOMIC DATA
Implementing Pharmacogenetics in Clinical Practice
Granting Access to Personal Health Information
Advancing the Utilization of Genomics Information
Building a Business Case for Genetic Testing
6 ETHICAL AND LEGAL ISSUES
Regulatory Issues
Ethical Issues: The Physician–Patient Relationship
Privacy Issues
Other Issues
7 WORKFORCE DEVELOPMENT
Knowledge, Skills Sets, and Training Opportunities
A Generation of Effort
8 ENVISIONING THE FUTURE
Maintaining Curated Databases
Databases for Genetic Variants Involved in Cancer
A Public Health Approach to Genomic Medicine
Return of Results
Getting Healthcare Providers Interested
Reimbursement for Interpretative Services
The Role of Industry
Final Words
REFERENCES
APPENDIXES
A WORKSHOP AGENDA
B SPEAKER BIOGRAPHICAL SKETCHES
C REGISTERED ATTENDEES